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Friday, December 31, 2021

Off-Topic: What was the best part of your year? - Bluebird Banter

We asked these questions last year when we thought 2021 would be so much better than 2020. So that’s what we get for optimism. The idea was stolen from Minor Leaguer.

Tell us the best thing that happened to you this year?

Tell us, what was the best part of this past baseball season for you?


The best thing for me this year?

That my immediate family made it through without getting sick, we are incredibly lucky.

Beyond that? Well, the gyms opened again, back in August. Getting to go workout has been great for my physical health, but likely even more for my mental health. I had been doing ok through Covid, going out for runs or walks most days. Then, this past summer, it got hot and smokey, and I stayed inside and ate.

So when the gyms opened, I searched for one that shared my interest in keeping me safe from Covid. It took some looking, but I found one where I felt safe. And I started playing squash and tennis, which gave me a bit of a social outlet and kept me moving.


The best part of the baseball season?

Watching Vlad become a star. He was so good. After having so many tell me that he was a bust, I enjoyed him this year. And hitting .315/.4441/.608 with RISP didn’t hurt.

My favourite part of baseball has always been watching young players develop. Often it doesn’t happen the way you would like it to but seeing young players grow into veterans, learn the game, work on weaknesses, build on strengths and become the player they were meant to be is the fun of baseball to me.

It is a lot like life, but quicker and with numbers.

Vlad became the player we thought he’d, but it happened suddenly.


Happy New Year.

I hope the New Year is a damn sight better than the old one and that, by the end of it, life is back to normal for all of us. But, I’ll admit, I’ve come to think that normal is a sliding scale.

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Off-Topic: What was the best part of your year? - Bluebird Banter
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FEEDBACK: Readers weigh in on this week's hot topics - OrilliaMatters

At the bottom of all local stories on OrilliaMatters, readers now have the option of submitting feedback. Here's what readers had to say about what was making news over the last week:

COLUMN: Line between right, wrong seems blurry at the moment 

Speaking for myself, in scenario #1, I would immediately leave the restaurant if someone in my group used fake ID. Requests to use our driveway, as in scenario #2, would be told politely NO. — John Winchester

Why would you go to a restaurant with someone you know doesn’t believe in vaccines? Why see them at all or expose them to your circle of relatives or friends? If you had not invited this person into your circle this issue would not have arisen. But when it did - just go home. — Tova Greenberg

The answer is easy in Situation Number 1. Leave. Your relative obviously cares nothing about your health and safety and is willing to put YOUR life on the line rather than do her civic and moral duty. Why would you stay in the same room as her? If you find the line between right and wrong to be blurry, maybe get some new glasses and do some serious thinking about actions, consequences and morality. —  Mark Elgar

Developer pitches plan for $16M retirement park in Ramara - Orillia News

How come this development will be built for the rich people from Toronto as our local seniors cannot afford $1,600 a month rent. — Antonius Dikmans

COLUMN: The family that puzzles together always picks up the pieces - Orillia News

I love this! I'm a puzzler and usually work alone but the family scene is clear in my mind. — Penny Kerr

Orillia resident sees red after being left in the dark for 21 hours

I agree that Hydro One customer service is dreadful. I have had more power outages since they took over than in the past seven years I have lived in Orillia. I finally got a generator they were so awful. — Marilyn Brown

'It's a sad thing': Salvation Army sees spike in need, especially among local seniors - Orillia News

Regarding the plight of seniors. Our provincial and federal government agree that $15/hour is a living wage. Doing the math regarding pensioners' CPP and OAS the government thinks seniors can survive on $5/hour. No wonder the Salvation Army are seeing increases at the food banks. Shame on the governments for not looking after the people who contributed to their pension but can’t afford to live off it. — Ian Richards

Local businessman set to welcome community to impressive rink - Orillia News

What a great idea. It's more fun skating outside anyway! —  Penny Kerr

City pauses recreation programs due to COVID-related staff shortage - Orillia News

Bummer. The assessment and testing situation is a fiasco - imposing huge costs and strains in both the public and private sectors. It's not like we didn't see this wave coming. Why wasn't the Ontario government prepared? — Mark Elgar


 

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FEEDBACK: Readers weigh in on this week's hot topics - OrilliaMatters
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Thursday, December 30, 2021

How Much Watching Time Do You Have This Weekend? - The New York Times

For this New Year’s weekend, our TV critic recommends the new seasons of “Queer Eye” and “Cobra Kai” or a political thriller for fans of “Homeland.”

Kelli O’Hara, center, in a scene from “The Accidental Wolf.”
Topic

‘The Accidental Wolf’

When to watch: Now, on Topic.

Kelli O’Hara stars as Katie, a wealthy woman who feels trapped in her life and marriage when a wrong-number — or was it? — phone call from what sounds like a war zone disrupts everything. “Wolf,” created and written by Arian Moayed, who plays Stewy on “Succession,” is a political and psychological thriller, as Katie’s quests put her in conflict with the authorities and her own family. The show’s first season was originally released as a web series in 2017; those chapters have been repackaged on Topic as four half-hour episodes, and the six-episode second season is now available. Start at the beginning.

Netflix

‘Cobra Kai’

When to watch: Season 4 arrives Friday, on Netflix.

This revival of the “Karate Kid” franchise remains way better than it has any right to be — self-aware, occasionally funny, more obsessed with fathering and father figures than any show in living memory. This season, Daniel and Johnny (Ralph Macchio and William Zabka) have to team up, though their aspirations of burying the hatchet don’t quite materialize, and instead they re-enact their lifelong rivalry through their respective children and karate students. “Cobra Kai” is one of the most physically violent current shows, with adolescents and people in their 70s alike beating one another senseless. If you enjoy nostalgia or are considering a martial arts-related New Year’s resolution, watch this.

Ilana Panich-Linsman/Netflix

‘Queer Eye’

When to watch: Season 6 arrives Friday, on Netflix.

The sixth season of “Queer Eye” takes the festivities to Texas, and just when you think the feel-good makeover formula is becoming too rote, something as simple as exposing one’s natural hairline becomes one of the bigger surprises I’ve seen on TV in a long time. “I have never been this shocked in my life!” gasps Jonathan Van Ness, and I agree. As always, Bobby Berk seemingly does the most, like building an entire house in one episode, and Antoni Porowski seemingly does the least, like offering encouragement while someone else bakes a cake. If you need emotional validation along with your couch time, watch this.

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How Much Watching Time Do You Have This Weekend? - The New York Times
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Funko Pops Are Buy One, Get One Free at Hot Topic - Comicbook.com

Holiday sales may be behind us for 2021, but there are still some end of the year deals to be had on Funko Pops. Several sales are happening right now, including a buy one, get one free sale at Hot Topic that includes exclusives.

See Hot Topic's Buy One, Get One Free Sale on Funko Pops

Hot Topic's buy one, get one free sale on Funko Pops offers up over 100 figures, and it's part of a sitewide B1G1 clearance sale that features over 1000 items. If that's not enough, you can also find a clearance sale on Funko Pops happening here at Walmart, and a 30% off Funko Pop exclusives sale here at GameStop. Some highlights from Hot Topics B1G1 free Funko Pop sale can be found below.

0comments

You can keep tabs on all of the latest and greatest Funko Pop releases right here. Some recent headlines include:

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Funko Pops Are Buy One, Get One Free at Hot Topic - Comicbook.com
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Wednesday, December 29, 2021

Watch now: BenFred explains why Rams relocation lawsuit was the topic of 2021 - STLtoday.com

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Watch now: BenFred explains why Rams relocation lawsuit was the topic of 2021  STLtoday.com
Watch now: BenFred explains why Rams relocation lawsuit was the topic of 2021 - STLtoday.com
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Big topics from around the world in 2021: Ethylene oxide, COVID-19 impact, global outbreaks - Food Safety News

– ANALYSIS –

A trio of issues that featured in the news agenda of 2020 carried into 2021 and none of them are out of sight yet. Coronavirus, the United Kingdom leaving the European Union, and ethylene oxide contamination are sure to demand coverage as we head into 2022.

2021 also gave us a glimpse into how pathogens don’t respect borders, Group B Streptococcus in Hong Kong, edible insect developments, and another year of big Salmonella outbreaks in the UK.

1) Impact of COVID-19 measures on foodborne infections

Some research has been done and more is ongoing to analyze the impact of the pandemic on the reporting of foodborne diseases. This was highlighted in full by the European Food Safety Authority (EFSA) and European Centre for Disease Prevention and Control (ECDC) report on outbreaks and illnesses in 2020. Regular Food Safety News readers will have guessed the direction of figures from coverage of national statistics, but the reported 47 percent decrease in outbreaks and 61 percent fall in illnesses might have surprised even them.

One interesting point was the agents that caused severe illness such as botulism or listeriosis didn’t go down as much as norovirus, for example, which is unpleasant but rarely fatal.

We know by now that many measures including reduced travel and closed food businesses are factors to consider, but more people were cooking at home so the risk areas changed. We’ll have to wait for the 2021 figures but I suspect with more travel and lab capacity back online they will go up. However, I would be surprised if we went back to the levels seen in 2019 pre-pandemic.

2) A global world: The international outbreaks

For the past three quarters, events involving the International Food Safety Authorities Network (INFOSAN) have gone up. Is this better reporting or more incidents? That depends on who you listen to, but we can agree this year saw some outbreaks involving Europe as well as the United States and Canada.

A multi-country outbreak of Salmonella Braenderup affected more than 350 people and was traced to Galia melons from Honduras. Four people were sick in the United States and two in Canada while most cases came from the UK and Europe.

Another example is the outbreak of different Salmonella types linked to tahini and halva from Syria. The United States has reported six Salmonella Mbandaka cases, one in 2020 and the rest this year. Canada has eight confirmed cases: five of Salmonella Mbandaka, two of Salmonella Havana and one of Salmonella Orion from 2019 to 2021. In Europe, at least 121 people have been affected since January 2019. With increased global trade and better technology to link infections, this multi-country aspect is something we may well see more of in the future.

3) Ethylene oxide incident

The number of recalls and withdrawals because of ethylene oxide in products must now be in the thousands, if not tens of thousands. Belgium first raised the alert in September 2020 concerning sesame seeds from India. It was later found in additives including locust bean gum (E410). The use of ethylene oxide to disinfect foodstuffs is not permitted in Europe. While it was to tackle Salmonella initially, some believe the examples of contamination could be because it is also applied to disinfect warehouses and transport containers.

The European Union has already tightened the rules and will go even further beginning in January 2022 to include ethylene oxide controls for imports of xanthan and guar gum, spices and some other products. We’ve seen not all EU countries are happy about the blanket recall approach and it has caused legal issues, but the long shelf life of products and the wide array of foods potentially affected means finding the right balance is tricky.

4) UK Salmonella outbreaks

Now that the UK has left the EU — we’ll get to that in a minute — outbreaks are not covered in as much detail in the EFSA and ECDC report mentioned above and the latest national figures published are from 2017. So, putting together pieces of the jigsaw we do have shines the spotlight on Salmonella again, as it was in the 2020 round-up.

We have the 139 Salmonella Enteritidis infections in 2021 as part of the nearly 900 cases linked to pet owners handling frozen feeder mice from 2014. The Salmonella Infantis pork scratching outbreak with 534 people sick is thought to be the largest one of this Salmonella type ever reported in Europe. Despite Tayto Group’s recall and halting production at the plant, illnesses were still being reported months after.

The UK was the most affected country with more than 100 confirmed patients in the melon outbreak referenced above and two strains of Salmonella Enteritidis in frozen, raw, breaded chicken products from Poland have caused more than 500 illnesses since January 2020 and one death.

5)  UK leaving the EU

There are many aspects to the UK no longer being an EU member state such as worker issues and losing access to systems like the Rapid Alert System for Food and Feed (RASFF).

One Brexit focus is the UK delaying border controls for food products from the EU. Checks on some EU imports, including fish, have been pushed back to November 2022. They have already been deferred three times. The EU implemented checks on similar items exported from Great Britain beginning in January 2021.

Certification and physical checks of high-risk animal-by products, all meats and meat products, and high-risk foods not of animal origin are set to start in July 2022, with controls on dairy products beginning in September and all other products of animal origin including composite and fish products beginning in November, according to the Institute of Export and International Trade.

The need to pre-notify the Animal and Plant Health Agency or Department for Environment, Food and Rural Affairs of sanitary and phytosanitary (SPS) imports from the EU, using the Import of Products, Animals, Food and Feed System (IPAFFS), comes into force on Jan. 1, 2022.

6)  Updated EU surveillance system

A new online portal started up for European public health authorities is designed to collect, analyze, share, and discuss disease data for threat detection, monitoring, risk assessment and outbreak response.

The European surveillance portal for infectious diseases (EpiPulse) was launched in June 2021 and integrates several surveillance systems such as The European Surveillance System (TESSy) and the five Epidemic Intelligence Information System (EPIS) platforms including the food and waterborne disease one. It is only open to appointed experts.

By June 2022, the joint European database is expected to be operational between EFSA’s whole genome sequencing database with isolates from food products and ECDC’s with clinical isolates from humans.

7) Group B Streptococcus in Hong Kong

Hong Kong reported an outbreak of Group B Streptococcus linked to handling fish with some cases belonging to sequence type 283 (ST283). This is the same type that affected up to 150 people in Singapore in 2015 from eating raw freshwater fish. Invasive GBS disease was not known to be foodborne before this incident. Nearly 20 infections were reported in July 2020 but the source was not found. Cases of invasive GBS ST283 have also been recorded in China, Lao People’s Democratic Republic, Thailand and Vietnam, according to the Food and Agriculture Organization (FAO) of the United Nations.

8) Edible insects

The EU is about to put house crickets on the list of novel foods, adding this insect to those approved as a food. It is the third insect to gain approval, following migratory locust and yellow mealworms. Novel food is anything that was not consumed in the EU to a significant degree before May 1997. There are also nine applications for insects, which are being evaluated by the European Food Safety Authority (EFSA).

This growing list brings many supply chain questions including safety. Hazards could be biological, including bacteria, viruses, fungi and parasites; chemical including mycotoxins, pesticides, heavy metals and antimicrobials; or physical. As part of addressing this, the FAO published an overview of food safety issues that could be associated with edible insects. Maybe in the future we will be giving storage, cooking and leftover advice for grasshoppers instead of chicken?

(To sign up for a free subscription to Food Safety News, click here.)

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Big topics from around the world in 2021: Ethylene oxide, COVID-19 impact, global outbreaks - Food Safety News
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Friday, December 24, 2021

Off Topic Thread: Favorite Christmas Movies - Bluebird Banter

It is Christmas Eve. And, unlike many years, I’m not running out to buy presents (though I think we could use some junk food in the house. I need chips at Christmas).

I do need to wrap today. It has been a long tradition that I wrap after everyone goes to bed on Christmas Eve. I’ve done it since the kids were little and I still do. I try to think of it as tradition and not laziness.

We got a ton of snow yesterday, so it looks very Christmasy.

We are having our Christmas a couple of days late this year, our son is coming up from Edmonton on the 27th.


What Christmas movies or TV specials that you can’t live without at this time of year?

I have to watch A Wonderful Life and Holiday Inn each year.

A Wonderful Life I’ve likely watched 50+ times. I can do all the lines. It’s always good to have a reminder about the importance of friends. “No man is a failure if he has friends”/I’ll admit to tearing up at the end every time I see it. The funny thing about the movie is that it wasn’t popular when it came out. It was too dark. People didn’t like it., but Jimmy Stewart would always name it when asked his favourite movie and, well, it was cheap to put on TV (someone forgot to renew the copyright), so it got played at Christmas over and over. Times changed. It didn’t seem so dark.

Add in that James Stewart would name it as his favourite movie any time asked and that through a mistake, the copywrite lapsed, and TV stations could play it basically for free.

It is kind of funny that the town of Bedford Falls is much more interesting in the time when he didn’t exist. But, as my son points out, the town is supposedly worse because there is more ethnic diversity. And, of course, his wife’s life is ruined because she has a career. Oh my god, a woman has a job, isn’t that awful.

Of course, my favourite and my most quoted line is: “You call this a happy family. Why’d we have to have so many children.” I relate to that line. (My wife would like me to tell you that I’m joking. She says I love my children.). But there are many many other lines I repeat a few dozen times a year. I make it a point of using the work malfeasance since mean old Mr. Potter uses it. I know I’ve typed “I suppose they do that sort of thing” referencing some MLB award that I don’t care about.

And the waitress at my favourite bar tires of me saying, “we serve hard drinks in here for men who want to get drunk fast, and we don’t need any characters around to give the joint atmosphere” (mostly because that bar insists on putting fruity beers in most of their taps). A line, I might add, is delivered perfectly in the movie.

Holiday Inn isn’t a great movie. You have to be a fan of old Hollywood musicals to like it. Bing Crosby at his best minimalist acting and great singing. Fred Astaire danced and showed off his limited acting ability. A pretty silly plot: Bing is lazy (maybe that’s why I can identify), opens an inn that will only be open on holidays, and, as always in these movies, they fight over a girl. Though with how they treat her, I have no idea why the girl would want either of them. Women in those movies didn’t have much choice in men.

I also watch the Alastair Sim Christmas Carol movie.

I have to watch these in the original black and white. I think colourizing is like remixing old music. I want the original vision of the artists.

And I love the original How the Grinch Stole Christmas. Not a movie, but I still like to see it. I loved Chuck Jones cartoons. I get a kick out of them doing extended version movies and wonder how they can pad out that little bit of story for an hour and a half. I used to need to see the Charlie Brown Christmas, but either it hasn’t aged well, or my tastes have changed.

And we are watching The Holiday, at the moment. Not

Anyway, those are my favourites, tell us about the ones you like best.

Enjoy your Christmas Eve.

Poll

My Favorite Christmas Movie is

  • 0%
    Home Alone
    (0 votes)
  • 3%
    Elf
    (1 vote)
  • 23%
    It’s a Wonderful Life
    (6 votes)
  • 23%
    Die Hard (not a Christmas movie to me)
    (6 votes)
  • 11%
    National Lampoon’s Christmas Vacation
    (3 votes)
  • 0%
    White Christmas
    (0 votes)
  • 3%
    Holiday Inn
    (1 vote)
  • 15%
    Christmas Carol
    (4 votes)
  • 0%
    Love Actually
    (0 votes)
  • 3%
    Bad Santa
    (1 vote)
  • 0%
    How the Grinch Stole Christmas (Jim Carry, not the tv cartoon)
    (0 votes)
  • 15%
    Something else
    (4 votes)
26 votes total Vote Now

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Off Topic Thread: Favorite Christmas Movies - Bluebird Banter
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Resilient Rosetown an Eager Topic of Discussion for Mayor Hay - WestCentralOnline.com

Local News Written by Cooper Douglas Friday, Dec 24 2021, 6:00 AM
Mayor Hay detailed all the interesting things going on in Rosetown over the past year, commending residents for their resiliency during the pandemic (Photo via Town of Rosetown)

Article continues below advertisement

Rosetown Mayor Trevor Hay should be happy with his past year at the helm in his hometown, and certainly hopes Rosetown residents are happy with the past 365 days as well. 

Some of the things that the mayor feels were accomplished in 2021 include an increased presence on social media, and an improved town website as a means for increased communication with the people. A good online community page is something that Hay believes keeps residents more than in the loop than ever. The Town of Rosetown Facebook page reminds its users that the page is meant to serve as a facilitator of discussion among people in the community, and to provide clarification on information to continue dialogue between residents. Using all of the available outlets including West Central Online is important to Hay.

“That helps get the message out there and make sure we have some open communication between the residents and ourselves.”

The mayor mentioned that some time was definitely spent catching new council members up on past projects in Rosetown, that Hay was so proud to list off when recapping the past year in the west central community.

“There’s lots of things,” beamed Hay, “We did a local improvement, three streets that were repaved. We did a new pool liner in a partnership with the RM of St. Andrews. We sold four lots, as we have a new west industrial park. There is a new vet clinic that opened up so that’s awesome. We renovated our two main bathrooms in the Civic Centre, and that was a big project we wanted to make sure got done because it’s been well needed for a lot of years.”

The Civic Centre renovations saw a little more work as some investigative work as Hay describes it had to be done beforehand, to assure stronger sewer lines and other things before the work began. Also noted was a $2.8 million grant from the federal and provincial governments to help with Rosetown’s lagoon expansion.

“We have been up against the wall with that one. Our environmental protection officer has hinted we need to get that done because we are at capacity, so with that grant coming through, that is a project that will be happening next year so that we are good for many years to come.”

The other critical things that Hay had to mention was the widening of the highway intersection in town, something that was heavily advocated for, and then also the creation of a new town staple in the Bark Park.

Bark Park Dogs Rosetownvia Town of Rosetown on Facebook

“The new dog park came together quite quickly, we utilized an area that wasn’t being used for anything,” he shared, “We had some supplies that we could utilize, and get that facility up and operating for residents at hardly any cost.”

Hay said expectations were definitely exceeded with all that went on in Rosetown this year. Especially despite the ever-changing COVID-19 situation. He is happy to see sports and other recreation activities back, and the province working together with Saskatchewan towns in providing testing to keep up with the evolving situation best as possible.

“So far so good, we are looking forward to down the road when things clear up, but there are these new variants coming out so people are being cautious, and it’s tough but we are getting through it.”

Everybody by now has their own opinion on what's going on, and Mayor Hay is just happy to see the amazing resiliency in his community.

“It’s kind of like the new normal, an accepted thing, and if everyone does their part to be cautious we will get through this,” said Hay, “It’s about adversity and overcoming some of these issues, resiliency, it’s good to see.”

Another thing that the mayor wanted to mention was the start of a recognition campaign for different town businesses through the town Facebook. Hay said it just recently started and should be a good way to share the people behind Rosetown businesses that make the Highway 7 hub tick.

“Thousands of cars drive thru daily, so there is a potential for people to stop in, spend a few dollars, and visit. It’s just huge, and I’m just really glad to be able to represent my community where I was born and raised.”

The last topic that was almost forgotten in speaking to Mayor Hay was the impromptu trip the Kindersley Jr. Klippers made to town. Ice plant issues in Kindersley forced the team to move their special Family Night for the players out of town, and Rosetown proved a gracious host as they got to watch some high level Junior A hockey.

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Resilient Rosetown an Eager Topic of Discussion for Mayor Hay - WestCentralOnline.com
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Thursday, December 23, 2021

ASH 2021: site selection key in reducing enrolment disparity in cancer trials - Clinical Trials Arena

ASH hot topic: site selection key in reducing disparity in cancer trials
Matching disease incidence and epidemiology with geography could be a way to improve enrolment disparity. Credit: Shutterstock

Diversity, equity, and inclusion in clinical trials was a hot topic in several abstracts presented at the recent Annual Meeting of the American Society of Hematology (ASH). Be it in terms of lacking representation of minority ethnic groups in clinical trial design, or the disparity in outcome indicators across different groups. Such issues are noticeable in indications like acute lymphoblastic leukemia (ALL).

Focusing on some of the potential disparities in children, adolescents, and young adults from minority ethnic backgrounds with ALL, the insights brought up by ASH abstracts #337 and #211 inspired expert ideas on how to how to improve such disparities. Researchers say that companies and institutions should pay close attention to clinical site locations to ensure that the sites are reflective of indications and their incidence in different populations. Additionally, collecting sociodemographic data of individual subjects could equally provide greater insight into some of the factors playing a role in a disparity in clinical trial outcomes.

ASH abstract argues for hotspot states

Institutions and companies can make their research more inclusive and insightful by focusing on clinical site locations, researchers tells Clinical Trials Arena. Taking part in preparing and presenting abstract #337 at this year’s ASH, Stanford University Medical Centre associate professor of medicine Dr Lori Muffly says matching clinical sites with areas representative of specific populations could mitigate enrollment disparity. Professionals could focus on what Muffly called “hotspot states”, which are areas with a high incidence of ALL, including states with large Hispanic populations such as California or Texas.

The abstract focused on the enrollment characteristics and outcomes of Hispanic and African American adolescent and young adult (AYA) subjects (age 18 – 40) with ALL. These patients took part in CALGB 10403 (NCT00558519), a Phase II clinical trial sponsored by the Alliance for Clinical Trials in Oncology. This population and data was subsequently compared to US population-wide data.

Despite that ALL remains a cancer with a higher incidence amongst a specific ethnic group, with over 40% of AYA (18 – 40 years in this case) ALL subjects grouped as Hispanic, Muffly says she has seen a discrepancy between the actual incidence of the indication and the enrolment of such individuals in clinical studies. More specifically, Muffly notes an underrepresentation of Hispanic subjects within the CALGB 10403 study, which led her to the abstract, she adds. Indeed, although this was a country-wide study, it only featured 45 subjects, about 15.3%, identified as Hispanic, despite they making up over 40% of AYA ALL subjects.

Fully omitting states such as Florida or Texas could have been an influential factor in causing a disparity of enrolment of Hispanic subjects.

Matching disease incidence and epidemiology with geography could be a way how to improve disparity of enrolment, Muffly says. This could be by considering areas with significant populations of respective minority groups. In case of CALGB 10403, Muffly notes the study focused a great deal of its clinical sites within the American Midwest, fully omitting states such as Florida or Texas, which could have been an influential factor in causing a disparity of enrolment of Hispanic subjects.

According to insights from GlobalData’s Pharma Intelligence Center, such disparities in enrollment appear to be much wider than in the case of the CALGB 10403 study. In 123 US-held ALL trials between 2004 and 2018, about 10.8% of subjects identified as Hispanic.

Linking disparity of enrolment and worse outcomes

While outcome disparity in clinical trial populations remains a complex topic, minimal enrollment of specific populations affected by a disease could be one of the reasons why some treatments are perhaps not as effective in those populations as they could have been, notes University of California San Francisco School of Medicine assistant professor of pediatrics Dr Lena Winestone. In simpler terms, if the appropriate populations are not represented, then the results could perhaps not be generalizable to that population, she adds.

Winestone has taken part in producing the #211 abstract presented at ASH 2021. The paper focused on racial, ethnic, and socioeconomic factors and their role in causing outcome disparities in a cohort of children and AYAs (age 0 – 30.99) with ALL who have taken part in the Children’s Oncology Group trials between the years 2004 and 2019. The paper examined the health outcomes of this cohort of newly-diagnosed ALL subjects. The paper found that non-Hispanic White subjects had the highest 5-year event-free (EFS) and overall survival (OS) rates, attaining 87.4% and 93.3%, respectively. In contrast, Hispanic subjects had an EFS of 82.8% and an OS of 90%, while non-Hispanic Black patients had an EFS of 81.9% and 89.8%.

Determining the causes for such disparities remains complicated and is likely an interplay of social determinants together with disease prognosticators, Winestone says. However, making sure that all populations are well-represented remains essential to allowing researchers and institutions to understand the factors playing a role in driving health inequities, notes Harvard Medical School assistant professor of pediatrics Dr. Kira Bona. If there are insufficient representative data from trials, professionals will not be able to ensure trial findings are generalisable to all populations and to intervene properly to improve equity in outcomes, she adds.

Reducing inequities also require a more systematic approach to collecting social determinants of health data for individual patients.

Yet to Bona, diversifying enrollment in clinical trials on its own is inadequate, reducing inequities also require a more systematic approach to collecting social determinants of health data for individual patients, which would allow professionals to understand modifiable links between such factors and outcome disparities.

Inequitable access to and enrollment on clinical trials is even more pronounced in adult populations, owing to the different models of healthcare delivery as compared to pediatric oncology necessitated by much larger overall number of adults affected by cancer, Bona says. Partly owing to fewer numbers of children affected by ALL, care can be focused in more centralized institutions, she adds, which can facilitate equitable trial participation.

According to data from GlobalData’s intelligence centre, in 21 trials with a cohort aged 25 and under between 2004 and 2018, about 13.7% of subjects were identified as Hispanic and 9.15% as African American. In case of the COG trials studied in the paper, 65.6% of the cohort identified as Non-Hispanic White, whereas 20.6 percent were grouped as Hispanic and 7.2% as Non-Hispanic Black.

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ASH 2021: site selection key in reducing enrolment disparity in cancer trials - Clinical Trials Arena
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Fans at Temple Got to Experience an Awesome Set by Topic - One EDM

Temple is one of San Francisco’s top nightclubs for electronic music. No matter if it is trance, techno, house, and so forth, Temple has hosted amazing talents inside its fantastic environment. Notable artists that headlined Temple include Alok, VOLAC, and Cat Dealers. On December 11, 2021, the famous Temple welcomed Topic, the German DJ/producer who is about to become one of the electronic music industry’s top superstars in the near future.

Topic is an expert in creating high-quality tracks in progressive house, slap house, future bass, and other broad EDM genres. The rising star DJ/producer’s must-hear bangers include “Your Love (9PM)“, his remake of ATB’s hit single, “9PM (Till I Come)“, and “Chain My Heart” alongside Bebe Rexha. Here is a short review of Topic’s awesome set at Temple in San Francisco on December 11th.

Topic provided a stellar atmosphere at Temple SF

Upon entering inside Temple, one might notice the VIP lounge couches that are on each side of the club. Furthermore, there is a second floor where people can still enjoy the music on both sides while consuming nice drinks. The area behind the decks and controllers was equally popping. Joining alongside Topic and his amazing team were attendees who got a great opportunity to experience a world-class artist producing a top-notch electronic music showcase.

Aside from playing the aforementioned “Your Love (9PM)”, and “Chain My Heart”, Topic at Temple SF also played other top tracks of his such as “My Heart Goes (La Di Da)“, “Why Do You Lie To Me“, and “Breaking Point“. The fans on the dance floor, as well as the people standing behind Topic, were having vibrant emotions altogether. This type of atmosphere on that night was just like any other night at Temple before the pandemic began. Overall, everyone had a fantastic time on December 11th getting to experience Topic’s addicting music.

Last words

Topic’s show at Temple on December 11th was the last stop on his USA tour. Whether if someone is seeing him inside a nightclub or at a music festival, they will not regret their time seeing a great artist. On November 15th, Topic just won an award for “Best International Dance Producer” at the Los40 Music Awards in Mallorca. Also since last week, “Your Love (9PM)”, became a 2022 BRIT Awards nominee for “International Song of the Year”. There are many grand things that are coming towards this exciting German producer in the near future.

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Wednesday, December 22, 2021

Off-Topic: Favourite Christmas Song - Bluebird Banter

We did the ‘Worst Christmas Song’ side of this earlier. Of course, since then, I heard a new nominee, a cover of the Beatles “Birthday,” but changed to Jesus’s Birthday. Fairly faithful in the music, but words slightly changed. I can’t find it to embed it here, but you don’t need to hear it. “It’s Jesus’s Birthday. We’re going to have a Party”. It got inclusive at the end “And Happy Hanukkah too, yeah.”

There should be a law against such things.

Anyway, favourite Christmas song?

I prefer the old traditional ones. We went to see Tom Jackson do his Christmas show in Banff last week, and the ones I liked the best were the sing-a-long songs.

But maybe my favourite is ‘The Christmas Song,’ written by Mel Torme and Bob Wells. A writer I like posted a great story about the song here. It is well worth the minute it takes to read it.

Anyway, share your favourite Christmas song.

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Wartsila modernises Paolo Topic ship with hybrid power solution - Ship Technology

Wartsila, along with Marfin Management and Solbian, has finished the deployment and commissioning of a hybrid power solution in combination with a PV solar energy system onboard a bulk carrier ship.

Under the management of Marfin Management S.A.M., the installation was performed onboard a 2016-built bulk carrier, M/V Paolo Topic, at Japan’s Onomichi Dockyard.

The integrated Wartsila HY Module capability encompasses an energy management system and batteries for supplying auxiliary power to the grid.

It can minimise environmental impact as well as reduce the cost of operations.

This is realised by cutting down maintenance requirements and fuel consumption.

Besides, the solution helps the vessel to reach a positive spot in connection with the industry’s Energy Efficiency Existing Ship (EEXI) and Carbon Intensity Indicator (CII) indexes.

Wartsila Marine Power business development director Giulio Tirelli said: “This installation represents a truly significant breakthrough in enabling the bulker fleet to increase both its economic competitiveness and environmental performance. The decarbonisation of shipping is a major priority for stakeholders throughout the maritime sector, and this unique solution helps us take a long step towards reaching this goal.”

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As a compact containerised technology, Wartsila HY Module for bulkers reduces a ship’s discharges by improving the onboard power generation, consumption, and management.

In a statement, Wartsila said: “The HY module gives the possibility to combine and integrate an energy storage system and additional energy sources, such as solar power, with Wartsila’s highly sophisticated Energy Management System (EMS) to deliver auxiliary power.”

The EMS is responsible for the management of engines, batteries, power distribution.

In combination with solar panels on the weather deck, this system is said to be the first such solution in the maritime space.

The containerised solution, which has been deployed without the requirement for dry-docking, has been put on the vessel’s deck for saving space.

Earlier this month, Wartsila Voyage partnered with Microsoft to support its efforts towards industrialising internet of things (IoT) for the shipping industry.

Related Companies
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Monday, December 20, 2021

Ladd Preservation Advocacy a Hot Topic for Duncanville - Focusdailynews

Ladd preservation Advocacy a hot topic
Holt photo of Five Mile Creek on Ladd property

Duncanville residents have grown increasingly involved in efforts to preserve a 42 acre tract of land off Danieldale Road and Santa Fe Trail. The Ladd family donated the land to the City some years ago, but retained ownership of seven acres on the tract. The deed restricts any commercial or residential development to less than 49% of the remaining 35 acres. Five Mile Creek runs through the property, along with a gas pipe line that makes development more difficult.

Ladd Preservation Advocacy

Members of the Ladd Preservation Advocacy group have attended several recent Duncanville City Council meetings to share their views on keeping the property as a nature preserve. Mark Graham, an outspoken member of the Ladd Advocacy Group, often contributes photos and information about the site. He has been instrumental in urging Duncanville residents to visit the property to see for themselves what a hidden jewel is located in the heart of their city.

Ladd Preservation Advocacy a hot topic
Holt photo

Here is an excerpt from one of Graham’s recent posts on the Ladd Preservation Advocacy blog: “…while I have been visiting the Ladd Land and Ten Mile Creek for much of the last ten years, I only got serious about posting images of the Ladd Land in the last few years. My goal was to raise awareness that the city wanted (to) develop a part of the land. As time went on, it became clear to me that the only way to prevent commercial or residential development was to have the land be declared a nature preserve.”

“No one has to agree with that but it is my goal. I want the land to remain natural forever and to have areas of it returned to a blackland prairie much as this whole area once was. A return of the open fields to become seas of native tall grasses, wildflowers, plus flowering plants that attract bees and butterflies is also what I hope for. Plants that once they take hold require little upkeep. I would love to see the fields returned to a state where they can be sustained with minimal human help.”

Ladd preservation advocacy a hot topic
Holt photo

Duncanville City Manager

Duncanville City Manager Aretha Ferrell-Benavides said, “The Ladd Property has been an enormous discussion for the City for a few years. Each time discussion starts, many of the efforts stop as many different views exist on the land’s best use. Upon my selection, I received a message from a developer interested in developing the property. This person was directed to our Economic Development Director, Gus Garcia, to explore further.”

“Based on his role over the EDC, he initiated a discussion with the EDC on the interest in the land. This is what started the most recent talks about the land. Given our City is over 90% developed, we do not have many options for further development, and given some of the recent state legislation, our property tax revenue is capped. As staff we are not pushing for the development of the land, but instead tasked to present options for what can be done with the land,” Ferrell-Benavides said.

Ladd preservation advocacy
Holt photo

“This is a hot topic, and with the other tasks ahead of the Economic Development team, I believe at this time we need to slow this process down and focus on other opportunities for redevelopment and development in the community,” she added.

Duncanville City Council meets every first and third Tuesday of the month, and their next meeting is Dec. 21 at 7 p.m. at City Hall. A final vote on approving the new single member district map is scheduled for the Dec. 21 meeting.

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Washington and quarterbacks: Always a hot topic - Redskins Wire

The more some things change, the more some things stay the same.

Every two years we have the national elections and then the mid-term elections. If that is not enough, in Washington, we are often getting new quarterbacks or needing a new one.

We still don’t know who will be playing Tuesday night as both Taylor Heinicke and Kyle Allen tested positive for COVID last week. Washington then went out and obtained Garrett Gilbert from the Patriots practice squad in case neither Heinicke or Allen can go Tuesday.

During a four-game losing streak, there was much talk of Washington needing to obtain a franchise quarterback again next off-season.

Taylor Heinicke then played well during a four-game winning streak, where his completion percentage, TD/INT ratio and QBR were all trending sharply in a positive direction. The talk of needing a new QB dwindled somewhat.

Then came last week against Dallas when Heinicke was only 11 of 25, lost a fumble for a TD, had an interception, and could of had a couple of more interceptions.

Suddenly, Twitter saw an increase in fans wanting a new QB next season.

Speaking of which Mel Kiper was talking quarterbacks this past week.

I simply can’t get that interested in talking quarterbacks at length, so a brief mention will need to suffice for now.

Kiper has Pittsburgh’s Kenny Pickett as his top-rated QB going into the bowl season.  Other quarterbacks listed for now by Kiper as possible first-round choices are Desmond Ridder of Cincinnati, Matt Corral of Ole Miss, and Malik Willis of Liberty.

I did notice Kiper gave additional mention of Sam Howell (North Carolina) as someone for now that he had ranked as a second-rounder.

You know the drill; quarterbacks will move the most up and down the board (mostly up) from now until the draft.

And Washington will continue to be linked to every available quarterback for 2022.

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Washington and quarterbacks: Always a hot topic - Redskins Wire
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Week of December 20 Off-Topic Open Thread - Japers' Rink

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Sunday, December 19, 2021

Off Topic: What is the worst Christmas song? - Bluebird Banter

I would kill for some baseball news. Not, you know, kill a person, but if I'd find something to kill. When I was very young, my dad took me with him when he went hunting. I was too young to fire a rifle, but my brother is 12 years older than me, and he was in the Air Cadets. So he had a rifle. I'll admit it didn't make me want to become a hunter.

When you live in Alberta, you know people who hunt. My father-in-law would go out hunting ducks (which is why my wife won't eat duck to this day, her mom wasn't the greatest of cooks, and it takes a bit of skill to make duck edible). But I've never fired any firearm. I tried archery a few years back, but I shot arrows at targets.

Anyway, I degrees...

We'll do the flip of this question later in the week, but I wanted to ask, "What is the worst Christmas song?" Last week we saw Tom Jackson's Christmas show and heard a few good Christmas songs. I like traditional ones (as long as they don't impose some disco beat on them).

This is still my answer:

There are rules in my life. Don't try to sing in a style you have no feel for. No old white guy should wake up in the morning and think, 'I'm going to rap today.' Or, in this case, sing reggae. Of course, I have kids that would mock me mercilessly if I tried to rap.

Also, one should never try to sing something in an accent that one doesn't actually own. For example, my dad loved old Scottish folk songs, but he grew up 10 miles from the border with Scotland. He also liked Harry Belafonte, but he shouldn't have tried to sing them with Belafonte's accent.

I’ll also admit that I also hate any Christmas song played before December 1st.

Anyway, please give us your choice for the worst Christmas song.

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Friday, December 17, 2021

Thursday, December 16, 2021

Hot Topic #57: The New Omicron Variant and What it May Mean for the Islands - Islands' Sounder

Submitted by San Juan County.

The rise of a worrisome new variant is front and center in headlines for good reason, but as is so often the case, finding the balance between irrational fear and legitimate concern is difficult. This hot topic will attempt to detail what the variant could mean for islanders and what we should be doing now to prepare.

Q: Haven’t there been other variants, why the worry about this one?

A: First off, it is critical to understand that we are early on in a very fast-moving situation. Information presented here is not meant to be definitive, but instead is a best sense of things based on what we know (and what we don’t know). Our understanding will change dramatically in the weeks to come.

Signs point to omicron spreading much more quickly than the delta variant. Omicron has been found in three Counties in WA to date (Pierce, King, and Thurston), a clear indicator that we will almost certainly see many more cases before long. Most experts would say it is likely that Omicron will be the dominant strain of the virus within the next couple of weeks to month.

Some research suggests that Omicron spreads twice as easily as Delta. If that is the case, we can expect a dramatic surge in case numbers, which will almost certainly lead to an unprecedented strain on healthcare infrastructure.

This potential for a sudden and unmanageable surge in cases is the reason we worry around Omicron.

Q: Does being vaccinated offer protection?

A: The expectation at this point is that being fully vaccinated against COVID will continue to offer significant protection against serious illness and death from all COVID variants, including Omicron. We may see some reduction in effectiveness but given the extremely high level of protection provided by the vaccines, vaccines remain a tremendously useful tool to protect ourselves from serious illness.

Some early research suggests that getting a third booster shot offers a significantly higher level of protection against Omicron than only two doses.

As with all previous COVID variants, the expectation is that Omicron will have far and away the most severe impact on those choosing to remain unvaccinated.

Q: OK, that sounds worrisome, but are things really that dire?

A: There is some early science that suggests the Omicron strain may end up being less severe than Delta, which would be good news and prevent this from being a worst-case scenario. However, a strain of COVID that is (for example) 15% less severe than Delta but which spreads twice as fast will still lead to a record surge in cases, and the inevitable hospitalizations and deaths (primarily in the unvaccinated) that follow. At the moment we are in a situation where we should be hoping for the best but preparing for a serious uptick in cases.

If that surge comes, we can expect that our healthcare systems will be stretched to their breaking points once again. Routine elective medical procedures will likely need to be postponed or cancelled, and those who need treatment for conditions not related to COVID may find access to care to be limited or impossible.

Q: So, what should we be doing to prepare?

A: Given that it will only be a couple of weeks at most until we know much more about Omicron, for now islanders should be thoughtful with their exposures. Clearly we have all relaxed our precautions considerably- but it would be wise to refresh our masking habits, and avoid situations where groups are indoors and unmasked in close proximity. If it turns out that the new variant is less worrisome than feared, we can quickly adjust once again. But, if Omicron does end up becoming a major concern, we’ll be grateful that we were prudent and cautious early on in its spread.

Clearly there are a large number of holiday gatherings and events happening across the islands these days. Organizers and attendees should be thoughtful about their participation, especially if unvaccinated or notably high risk. And all islanders should recognize that we may need to rapidly adjust our plans and expectations based on how things with the Omicron variant unfold.

If you or your family are not yet vaccinated, now is the time to do it. The County is hosting free clinics this coming week and signing up and getting your shot is the single most important thing you can do to keep yourself and those you care about healthy. SIGN UP HERE.

The County will also be giving boosters for those 18+ who are fully vaccinated at the same clinics. Again, SIGN UP HERE

In addition, the County Health Department is making a supply of more than 3,000 free PCR test kits available to the community to help support safe holiday travel and socializing. These are mail in tests that should be used by islanders if they are feeling symptomatic or have been exposed to a COVID positive individual. The supply is limited, but kits will be distributed free of charge beginning on December 13th. Details on how to pick up the kits will be released later this week.

Q: Will the rise of Omicron lead to changes in regulations or requirements?

A: What the future holds is entirely dependent on what we see happening with the spread and impacts of the disease, both here and elsewhere. If it becomes clear that Omicron is a threat to our healthcare system, we can expect more aggressive enforcement of masking requirements, and perhaps additional requirements around vaccinations.

At this point in the pandemic, it is abundantly clear that the vast majority of hospitalizations and fatalities are in unvaccinated individuals. In order to better protect both those who choose to remain unvaccinated and perhaps more importantly, to help minimize impacts to the greater healthcare system should Omicron spread rapidly, additional requirements may be needed. As always, the key is to remain patient and flexible and let decisions be dictated by science and experience, not by emotion or wishful thinking.

Q: What should I do if I or someone I know tests positive, especially if we start seeing large numbers of Omicron cases?

A: To start, know that the County Health Department Surveillance Team was stretched to their limit by the high number of cases in November. If case rates increase dramatically, the nature of contact tracing is going to be scaled back and far more responsibility will be placed on individuals. Any islanders who test positive for COVID will likely be asked to notify their own close contacts and to take their own steps to ensure that they minimize the opportunity for disease spread. The Health Department will provide basic initial guidance but will not be able to support the high level of attention that has been provided to date. Islanders will be asked to place greater trust in those that they interact with indoors and unmasked, and if cases spiral, you will be counting on those people you are interacting with to notify you directly if they test positive.

Q: That’s a lot of info, can you give me the basics?

A: Yes. In short: -While there is no need for panic, there is genuine cause for concern with Omicron.-Fortunately, all of the usual precautions that we know work well (masking and vaccination) should continue to work well. -This will be a fast-moving situation. Be cautious over the next couple of weeks until we know more. -Stay patient. We’ll get through this too.

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Hot Topic #57: The New Omicron Variant and What it May Mean for the Islands - Islands' Sounder
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Pele's goal count a topic of debate - CTV News

Nobody disputes Pele's greatness and his penchant for scoring. The exact number of goals in his career will forever be a topic for deba...